Hi Anton83, welcome!
I currently use supplements only, which work better for me than prescribed medications.
I have had lots of success adding magnesium to my supplement list, but I don't use much zinc. Now I take vitamin D, St. John's wort, Omega3, iron, and choline, among others. It's taken years to find the right combination! And even now, I still need to tweak it when my symptoms change.
As Rosie mentioned (and as you probably know), it's different for everyone. What works for you may not work for me and viceversa. Just remember to document your efforts so that you can keep accurate track of what works and what doesn't.
You might want to check out my article about supplements used for depression here: Supplements Used for Depression
Let us know how it goes!