I find it's a bit easier (although not half as fun) to clean up and put away after each project, especially since I quilt, sew, scrapbook, bead, crochet, and paint in the same room. Granted it's a large room - 12 1/2 x 28ft - but if I don't clean up after each project, the mess gets out of hand and I get overwhelmed. I also have 3 large trashcans and 3 small counter-top trashcans, as well as boxes here and there for scraps. It helps tremendously.
Hope this helps.
Stephanie