Have a good spam catcher in place, Akismet is pretty good for WordPress, it will immediately weed out spam based on types of comments and links left.
Also, whenever I setup a blog I adjust the Discussions area under the Settings tab to make sure I review any comment left with one or more links. I also require that commenters must leave their name and email.
This is a good start to minimizing spam.
Last edited by Vi - Blogs/Social Network; 08/29/11 12:10 PM.