Because of my health issues, I'm already giving up some things, like travel (even to the next town over). It's difficult. I'm lucky that I have a wonderful friend and roommate that takes care of me (she's also an RN, and stubborn, and bossy sometimes LOL). My sons are all grown, but don't live here, so luckily my friend and I had needs that we could meet in each other. She needed someone to help care for her aged dog (he's still around 5 years later) and was ending a marriage, so living with me helped her meet her living needs.
I shudder at the thought of someday possibily giving up my computers, sewing machines and yarns. Giving up my dogs would absolutely upset me to no end (I have 3 all lapdogs). Not to mention, I'd have to live on someone else's schedule. For me, that's a real challenge