All of your twos (2:22:22 on April 22) add up to the number 14 which factors down to the number 5 (4+1).
5 is the number of harmony and balance. It is also the number of the divine grace - in Chrisianity.
5 is the symbol of the perfection in the Mayas.
In the numerology thought, 5 is expansiveness, visionary, adventure, the constructive use of freedom.
If you go strictly by a single # repeating itself you would use the symbolic meaning of that number, as Chi did. If you go by numerology methods, you add up all the numbers and reduce it down to a single number then find the meaning of the single number.
Here is a good link to explain numerology:
Numerology Expresson