One of the bugs with tweetdeck is that you can't add anyone to a list of they have not tweeted recently. So for me I just have to keep working on updating my lists, as different people go back to twitter at different times.
For you, Lisa, you should probably make a list of "frequently tweeting editors" and "Once a day editors"...that would clean up your feeds a great deal.
For me, I have a separate category for for personal friends, one for networking acquaintances, one for news outlets, one for humor type follows (like Darth Vader, the cast of Firefly and Buffy, Fake Bill Clinton), one for big name bloggers/internet marketers...
That's the beauty of Tweetdeck. You organize it as you see fit. My personal friends one is the snallest list, but indeed the one i find most compelling.