Wine is a food product, and can be "spoiled" in several ways. First, never store your wine in a hot area - this includes your car, in racking over the fridge, in a hot kitchen, and when being shipped via a non-refridgerated method, etc. you can easily "cook" your wine that way. Cooked wine will taste like stewed fruit, and can have pruny characteristics. It won't hurt you, but won't taste like it should. You will also encounter wine which is corked. This means the wine has been spoiled via a chemical reaction between the cork and various chemical agents, such as bleach used in cleaning the winery. Once you have tasted/smelled a corked wine, you'll never forget it. The level of corkiness varies, as does the ability of the taster to detect it, but will have scents ranging from wet dog to moldy newspaper. The wine will be dull tasting, no vibrant flavors and at the worst end, be totatlly undrinkable. It doesn't have any health effects, you just won't enjoy it.