Living a life of consequence is all about owning your choices. I am CF... I was CF before I was diagnosed with PCOS and irreversible infertility. When asked, I don't say "I can't have kids," I say, "I don't want children." And I take whatever reactions I get as a direct consequence of stating a personal choice... I have my own personal issues with rude, nosy people asking me questions that are none of their business to begin with, but that's not the point.
I'm also fat. I don't diet. I'd rather not exercise beyond what I do at work or for fun. Its part of who I am. I don't spend a lot of time bemoaning the fact that I'm not societally average... I learned to embrace myself as I am, extra curves and all.
My choices work for me. I'm not proud of all of them, and some of them proved to be rather dangerous. I don't really believe in regret, beyond regretting the pain that I accidentally cause people I care about... Every single choice I have made, good or bad, has molded me into the person I am today, and I really (after a lot of soul searching) like the person I am today. But my choices wouldn't work for anyone else. I have friends who are as fulfilled with their fitness routines and their diets as I am without them. The same goes for children, the same goes for any of my life's choices.
I feel for people who regret their choices. I can't imagine being that unhappy with my life. But you're right... Its important to be proud of who you are and the life you've built... And if you're not, then perhaps working toward happiness and pride in your life is something you should do.