I agree Nancy - you want it to be key word rich, but also so it sounds like a human being wrote it

I don't use # keywords at all. How some people use them is like this -
Make a wine cork reindeer from a Champagne cork! #wine
So you give a specific keyword that starts with a # sign, and that lets you get found in searches where people are looking for #wine. It's a way to indicate your post is REALLY about wine and that wine isnt' just a random word in the sentence.
I use TweetDeck to manage my posts, I've never used twibe.