Rosie,
Although Zofran does not make me feel "different", I know the feeling you are talking about. It is almost a disconnect from who you are. I would not like that feeling either. I think each case is different, it is important not to have attacks that keep you locked away from the world but if you can't truly enjoy the world because of your medication, what good is it. Kinda a catch twenty-two.

You've been through a lot in your life, you deserve to have the best.
Colleen