I've been waiting for a response from any one more qualified than I consider myself. But since no one has, this is my opinion.
I think, in all cases, when a quilt is finished and before it is used or given to someone it needs to be cleaned. Clean it in whatever manner is necessary based on the fabrics - in my 'world' that is machine washing.
If you expect your gift to be used, you should expect that it will need to be cleaned from time to time. Clean it however you would recommend to your gift recipient. (If you will be machine washing, you should probably use a spot treatment with a degreaser.)
That's all I can offer. GrannyH