Oh yes... I can definitely tell when my hormones are getting out of balance. Back in late 2006, I was actually experiencing hormonal imbalance, but my docs just treated me like I was depressed and anxious (which I was, it's just that it was hormone related), and the meds me worse! Worse?!!
I'm so glad I got that straightened out. I still feel off balance, and out of sorts sometimes, but generally I do pretty well.