Yesterday I watched Zero Hour! (1957) starring Dana Andrews, Linda Darnell and Sterling Hayden.
I think this movie could be the grand-daddy of all those "is there anyone on board who can fly this plane" movies that came along in later years.
Dana Andrews plays a burned-out former WW2 fighter pilot, Darnell is his wife who may be on the verge of leaving, and Hayden plays the commercial pilot who - along with his co-pilot and several passengers - succumbs to food poisoning thanks to some dodgy fish.
It's all great fun, and of course the plane lands safely!