I thought that Kyle XY looked interesting, but I've never watched. Has it been out long? That may be one I rent a season at a time on DVD.
Kyle XY debuted in summer of 2006. The first season was only 10 episodes and is available on DVD now. The second season is still airing, but it will be 23 episodes when it is done.
This show is definitely "sci-fi lite" :-). You don't get a whole lot of techno-babble on this show; it is more about the emotions. One of my guilty pleasures is teen shows like Degrassi, so Kyle XY is a perfect blend of teen drama and special powers.