I'm on the web practically 24 hours a day and my wrist is really killing me now. I took the advice from one of the articles I read here and stopped using my mouse wrist rest (it was a cool slidy one) and have a cordless mouse. But it didn't help much.
I just found this really neat product - it lets you rest the mouse on your knee instead of up on a table. The reviews from it are pretty amazing. Has anyone tried this?
http://www.kmat.ndo.co.uk/ I just ordered one and will report back on how it works.